Partial loss of parvalbumin‐containing hippocampal interneurons in dementia with Lewy bodies
Identifieur interne : 000199 ( Main/Exploration ); précédent : 000198; suivant : 000200Partial loss of parvalbumin‐containing hippocampal interneurons in dementia with Lewy bodies
Auteurs : Hans-Gert Bernstein ; Mary Johnson ; Robert H. Perry ; Fiona E. N. Lebeau [Royaume-Uni] ; Henrik Dobrowolny ; Bernhard Bogerts ; Elaine K. PerrySource :
- Neuropathology [ 0919-6544 ] ; 2011-02.
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Abstract
Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia. Among many other neuropathological changes in DLB, brain region‐specific cellular deficits have been reported. They include decreases in motor neuron and pyramidal cell densities, while neocortical parvalbumin (parv)‐containing neurons are thought to be free of Lewy bodies and spared in DLB. However, elevated parv levels are found in the cerebrospinal fluid of patients suffering from dementia with Lewy bodies. We performed an immunohistochemical analysis of hippocampal parv‐immunoreactive neurons in well‐characterised DLB cases and from controls using a specific antibody against the calcium binding protein. In addition, an analysis of the regional and cellular distribution of alpha‐synuclein was carried out. Subfield and laminar distribution of parv‐immunoreactive (ir) neurons on the hippocampus in subjects with DLB and controls were present exclusively as non‐granule cells of the dentate gyrus (DG)/hilus and non‐pyramidal cells of CA1, CA2, CA3 and CA4 areas of the hippocampus. The distribution patterns did not differ qualitatively between DLB and controls. Quantitative estimation of parv‐ir neuron density revealed significant decreases in the dentate (DG)/hilus region as well as in the CA1 subfield. Double immunolabelling experiments showed that only 2% of parv expressing interneurons were laden with alpha‐synuclein immunoreactive material. No significant changes were found for the total neuron densities in DLB cases. Our results show a partial loss of parv‐expressing hippocampal interneurons in DLB, which might be the result of long‐lasting calcium overload in combination with a proposed impaired mitochondrial function. It remains to be elucidated if the numerical decrease of this particular subset of hippocampal interneurons has consequences for the gamma (20–80 Hz) frequency activity in DLB patients.
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DOI: 10.1111/j.1440-1789.2010.01117.x
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Perry</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Neuropathology</title><idno type="ISSN">0919-6544</idno><idno type="eISSN">1440-1789</idno><imprint><publisher>Blackwell Publishing Asia</publisher><pubPlace>Melbourne, Australia</pubPlace><date type="published" when="2011-02">2011-02</date><biblScope unit="volume">31</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="1">1</biblScope><biblScope unit="page" to="10">10</biblScope></imprint><idno type="ISSN">0919-6544</idno></series><idno type="istex">CF464B492E4461E1690D376DF50EC31A0524A5D2</idno><idno type="DOI">10.1111/j.1440-1789.2010.01117.x</idno><idno type="ArticleID">NEUP1117</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0919-6544</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>alpha‐synuclein</term><term>dementia with Lewy bodies</term><term>hippocampus</term><term>interneurons</term><term>morphometry</term><term>parvalbumin</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia. Among many other neuropathological changes in DLB, brain region‐specific cellular deficits have been reported. They include decreases in motor neuron and pyramidal cell densities, while neocortical parvalbumin (parv)‐containing neurons are thought to be free of Lewy bodies and spared in DLB. However, elevated parv levels are found in the cerebrospinal fluid of patients suffering from dementia with Lewy bodies. We performed an immunohistochemical analysis of hippocampal parv‐immunoreactive neurons in well‐characterised DLB cases and from controls using a specific antibody against the calcium binding protein. In addition, an analysis of the regional and cellular distribution of alpha‐synuclein was carried out. Subfield and laminar distribution of parv‐immunoreactive (ir) neurons on the hippocampus in subjects with DLB and controls were present exclusively as non‐granule cells of the dentate gyrus (DG)/hilus and non‐pyramidal cells of CA1, CA2, CA3 and CA4 areas of the hippocampus. The distribution patterns did not differ qualitatively between DLB and controls. Quantitative estimation of parv‐ir neuron density revealed significant decreases in the dentate (DG)/hilus region as well as in the CA1 subfield. Double immunolabelling experiments showed that only 2% of parv expressing interneurons were laden with alpha‐synuclein immunoreactive material. No significant changes were found for the total neuron densities in DLB cases. Our results show a partial loss of parv‐expressing hippocampal interneurons in DLB, which might be the result of long‐lasting calcium overload in combination with a proposed impaired mitochondrial function. It remains to be elucidated if the numerical decrease of this particular subset of hippocampal interneurons has consequences for the gamma (20–80 Hz) frequency activity in DLB patients.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><noCountry><name sortKey="Bernstein, Hans Ert" sort="Bernstein, Hans Ert" uniqKey="Bernstein H" first="Hans-Gert" last="Bernstein">Hans-Gert Bernstein</name><name sortKey="Bogerts, Bernhard" sort="Bogerts, Bernhard" uniqKey="Bogerts B" first="Bernhard" last="Bogerts">Bernhard Bogerts</name><name sortKey="Dobrowolny, Henrik" sort="Dobrowolny, Henrik" uniqKey="Dobrowolny H" first="Henrik" last="Dobrowolny">Henrik Dobrowolny</name><name sortKey="Johnson, Mary" sort="Johnson, Mary" uniqKey="Johnson M" first="Mary" last="Johnson">Mary Johnson</name><name sortKey="Perry, Elaine K" sort="Perry, Elaine K" uniqKey="Perry E" first="Elaine K." last="Perry">Elaine K. Perry</name><name sortKey="Perry, Robert H" sort="Perry, Robert H" uniqKey="Perry R" first="Robert H." last="Perry">Robert H. Perry</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Lebeau, Fiona E N" sort="Lebeau, Fiona E N" uniqKey="Lebeau F" first="Fiona E. N." last="Lebeau">Fiona E. N. Lebeau</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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